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Retatrutide

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Retatrutide (LY-3437943) is a synthetic peptide engineered as a unimolecular triple agonist at the GLP-1, GIP, and glucagon receptors. It is used in advanced metabolic research to investigate incretin biology, energy balance, and cardiometabolic endpoints.

$42.95

Research Use Only: Products are intended solely for laboratory research and analytical purposes. Unless explicitly stated otherwise, they are not intended for use in diagnostic procedures, food, drugs, medical devices, cosmetics, or for human or animal consumption.

$42.95

Research Use Only: Products are intended solely for laboratory research and analytical purposes. Unless explicitly stated otherwise, they are not intended for use in diagnostic procedures, food, drugs, medical devices, cosmetics, or for human or animal consumption.

Description

Retatrutide is a 39-residue, lipid-modified peptide specifically designed to activate three class B GPCRs: the GLP-1 receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor. Structural work using cryo-EM has shown that retatrutide engages conserved peptide-binding motifs on each receptor while also inducing receptor-specific conformations that support simultaneous triple agonism.

In metabolic research, retatrutide is employed as a tool compound for obesity, diabetes, and NAFLD/NASH models. Phase 2 clinical studies have reported large reductions in body weight and improvements in glycemic control and liver-fat markers, making it a benchmark molecule for exploring multi-receptor incretin pharmacology. Preclinical and translational experiments assess endpoints such as body-weight trajectories, energy expenditure, lipid handling, hepatic fat content, and pancreatic islet function.

  • Store in a cool, dry, and dark environment. Refrigerate after reconstitution.
  • Keep away from direct sunlight and heat sources
  • Store at -20C for long-term storage
  • Once reconstituted, store at 2-8C and use within 2-3 weeks
  • Avoid repeated freeze-thaw cycles

Retatrutide – 10mg
(Batch 7438)
Avg. Purity: 99.105%
Avg. Mass: 10.39mg
Result Date: January 16, 2026
Date Added: January 16, 2026
View Lab Results

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