Description
Selank was designed by fusing the native tuftsin sequence with an additional Pro-Gly-Pro motif to enhance metabolic stability and extend duration of action. As a tuftsin analogue, it has been studied for its capacity to influence both immune parameters and central nervous system signaling. Preclinical work indicates effects on cytokine balance (including IL-6), T-helper profiles, and expression of neurotrophic factors such as BDNF in the hippocampus.
In neurobehavioral models, Selank has been investigated for its anxiolytic-like and nootropic-like properties, often in comparison or combination with Semax. Mechanistic studies suggest modulation of monoamine turnover, GABAergic tone, and peptidase activity that regulates endogenous enkephalins and related peptides. This makes Selank a versatile research tool for dissecting the intersections of stress, mood, immunity, and cognition.
